長崎大学大学院医歯薬学総合研究科 内臓機能生理学
Department of Physiology of Visceral Function and Body Fluid, Graduate School of Biomedical Sciences, Nagasaki University 

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  • Peter JK, Umene R#, Wu CH, Nakamura Y, Washimine N, Yamamoto R, Ngugi C, Linge K, Kweri JK, Inoue T#. #Co-corresponding author. Renal macrophages induce hypertension and kidney fibrosis in Angiotensin II salt mice model. Biochem Biophys Res Commun, in press.
  • Soejima S*, Wu CH*, Matsus H, Terakado M, Okano S, Inoue T, Kumai Y. *Equally contributed. Swallowing-related muscle inflammation and fibrosis induced by a single dose of radiation exposure in mice. Lab Anim Res, 40:12, 2024
  • Inoue T*, Umene R*, Sung SJ, Tanaka S, Huang L, Yao J, Hashimoto N, Wu CH, Nakamura Y, Nishino T, Ye H, Rosin DL, Ishihara K and Okusa MD. *Equally contributed. Bone marrow stromal cell antigen-1 deficiency protects from acute kidney injury. Am J Physiol Renal Physiol, 326(2):F167-F177, 2024
  • Macalinao ML, Inoue S, Tsogtsaikhan S, Matsumoto H, Bayarsaikhan G, ian J, Kimura K, Yasumizu Y, Inoue T, Yoshida H, Hafalla J, Kimura D, Yui K. IL‐27 produced during acute malaria infection regulates Plasmodium‐specific memory CD4+ T cells. EMBO Mol Med, e17713, 2023
  • Nakamura Y and Inoue T#. #Corresponding author. Tolerogenic dendritic cells: promising cell therapy for acute kidney injury. Kidney Int, 104:420-422, 2023
  • Nakamura Y, Matsumoto H, Wu CH, Fukaya D, Uni R, Hirakawa Y, Katagiri M, Yamada S, Ko T, Nomura S, Wada Y, Komuro I, Nangaku M, Inagi R, and Inoue T#. #Corresponding author. Alpha 7 nicotinic acetylcholine receptors signaling boosts cell-cell interactions in macrophages effecting anti-inflammatory and organ protection. Commun Biol, 6:666, 2023
  • Umene R, Nakamura Y, Wu CH, Muta K, Nishino T# and Inoue T#. #Co-corresponding author. Induction of tetraspanin 13 contributes to the synergistic anti-inflammatory effects of parasympathetic and sympathetic stimulation in macrophages. Biochem Biophys Res Commun,665:187-194, 2023
  • Abe C, Katayama C, Bazek M, Nakamura Y, Ohbayashi K, Horii K, Fujimoto C, Tanida M, Iwasaki Y, Inoue T, Nin F, Morita H. Repeated activation of C1 neurons in medulla oblongata decreases anti-inflammatory effect via the hypofunction of the adrenal gland adrenergic response. Brain Behav Immun,111:138-150, 2023
  • Chen JH, Wu CH, Jheng JR, ChaoCT, Huang JW, Hung KY, Liu SH, Chiang CK. The down-regulation of XBP1, an unfolded protein response effector, promotes acute kidney injury to chronic kidney disease transition. J Biomed Sci, 29(1):46, 2022
  • Inoue T*, Nakamura Y*, Tanaka S, Kohro T, Li LX, Huang L, Yao J, Kawamura S, Inoue R, Nishi H, Fukaya D, Uni R, Hasegawa S, Inagi R, Umene RWu CH, Ye H, Bajwa A, Rosin DL, Ishihara K, Nangaku M, Wada Y and Okusa MD. *Equally contributed. Bone marrow stromal cell antigen-1 (CD157) regulated by sphingosine kinase 2 mediates kidney fibrosis. Front Med (Lausanne), 9:993698, 2022
  • Tanaka S, Zheng S, Kharel Y, Fritzemeier RG, Huang T, Foster D, Poudel N, Goggins E, Yamaoka Y, Rudnicka KP, Lipsey JE, Radel HV, Ryuh SM, Inoue T, Yao J, Rosin DL, Schwab SR, Santos WL, Lynch KR, Okusa MD. S1P signaling in perivascular cells enhances inflammation and fibrosis in the kidney. Science Trans Med, 14(658):eabj2681, 2022
  • Yamamoto K, Hosogaya N, Inoue T, Jounai K, Tsuji R, Fujiwara D, Yanagihara K, Izumikawa K, Mukae H. Efficacy of Lactococcus lactisstrain plasma (LC-Plasma) in easing symptoms in patients with mild COVID-19: protocol for an exploratory, multicentre, double-blinded, randomised controlled trial (PLATEAU study). BMJ Open, 12(9):e061172, 2022
  • Yang A, Liu B, Inoue T. Role of autonomic system imbalance in neurogenic pulmonary oedema. Eur J Neurosci, 55(6):1645-1657, 2022
  • Wu CH, Inoue T#, Nakamura Y, Uni R, Hasegawa S, Maekawa H, Sugahara M, Wada Y, Tanaka T, Nangaku M, Inagi R. #Corresponding author. Activation of α7 nicotinic acetylcholine receptors attenuates monocyte–endothelial adhesion through FUT7 inhibition. Biochem Biophys Res Commun, 590:89-96, 2022
  • Yoshioka K, Hirakawa Y, Kurano M, Ube Y, Ono Y, Kojima K, Iwama T, Kano K, Hasegawa S, Inoue T, Shimada T, Aoki J, Yatomi Y, Nangaku M, Inagi R. Lysophosphatidylcholine mediates fast decline in kidney function in diabetic kidney disease. Kidney Int, 101(3):510-526, 2022
  • Fujii R, Hasegawa S, Maekawa H, Inoue T, Yoshioka K, Uni R, Ikeda Y, Nangaku M, Inagi R. Decreased IFT88 expression with primary cilia shortening causes mitochondrial dysfunction in cisplatin-induced tubular injury. Am J Physiol Renal Physiol, 321(3):F278-F292, 2021
  • Chen JH, Wu CHChiang CK. Approaches Targeting Proteostasis in Kidney Disease and Fibrosis. Int J Mol Sci, 22(16):8674, 2021
  • Hasegawa S, Inoue T#, Nakamura Y, Fukaya D, Uni R, Wu CH, Fujii R, Peerapanyasut W, Taguchi A, Kohro T, Yamada S, Katagiri M, Ko T, Nomura S, Ozeki NA, Susaki EA, Ueda HR, Akimitsu N, Wada Y, Komuro I, Nangaku M, and Inagi R. #Corresponding author. Activation of sympathetic signaling in macrophages blocks systemic inflammation and protects against renal ischemia/reperfusion injury. J Am Soc Nephrol, 32 (7) 1599-1615, 2021
  • Inoue T#. #Corresponding author. Neuroimmune system-mediated renal protection mechanisms. Clin Exp Nephrol,25:915–924, 2021
  • Tanaka S, Abe C, Abbott SB, Zheng S, Yamaoka Y, Lipsey JE, Skrypnyk NI, Yao J, Inoue T, Nash WT, Stornetta DS, Rosin DL, Stornetta RL, Guyenet PG, Okusa MD. Vagus nerve stimulation activates two distinct neuro-immune circuits converging in the spleen to protect mice from kidney injury. Proc Natl Acad Sci U S A, 118(12):e2021758118, 2021
  • Uni R, Inoue T#, Nakamura Y, Fukaya D, Hasegawa S, Wu CH, Fujii R, Surattichaiyakul B, Peerapanyasut W, Ozeki A, Akimitsu N, Wada Y, Nangaku M, Inagi R. #Corresponding author. Vagus nerve stimulation even after injury ameliorates cisplatin-induced nephropathy via reducing macrophage infiltration. Sci Rep, 10(1):9472, 2020
  • Nakamura Y, Inoue T#. #Corresponding author. Neuroimmune communication in kidney. JMA Journal, 3(3):164-174, 2020
  • Higashijima Y, Matsui Y, Shimamura T, Nakaki R, Nagai N, Tsutsumi S, Abe Y, Link VM, Osaka M, Yoshida M, Watanabe R, Tanaka T, Taguchi A, Miura M, Ruan X, Li G, Inoue T, Nangaku M, Kimura H, Furukawa T, Aburatani H, Wada Y, Ruan Y, Glass CK, Kanki Y. Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells. EMBO J, 39(7):e103949, 2020
  • Maekawa H, Inoue T, Ouchi H, Jao TM, Inoue R, Nishi H, Fujii R, Ishidate F, Tanaka T, Tanaka Y, Hirokawa N, Nangaku M, Inagi R. Mitochondrial Damage Causes Inflammation Via cGAS-STING Signaling in Acute Kidney Injury. Cell Reports, 29(5):1261-1273, 2019
  • Uni R, Abe C, Inagi R and Inoue T#. #Corresponding author. Role of the nervous system in acute kidney injury. Contemporary Acute Kidney Injury and Regenerative Medicine. Yoshio Terada, Takashi Wada, Kent Doi (Eds.) Springer Nature Singapore Pte Ltd. 2020. p.297-316.
  • Hasegawa S, Inoue T# and Inagi R. #Corresponding author. Neuroimmune interactions and kidney disease. Kidney Res Clin Pract, 38(3):282-294, 2019
  • Inoue T, Maekawa H, Inagi R. Organelle crosstalk in the kidney. Kidney Int, 95(6):1318-1325, 2019
  • Jao T, Nangaku M, Wu CW, Sugahara M, Saito H, Maekawa H, Ishimoto Y, Aoe M, Inoue T, Tanaka T, Staels B, Mori K and Inagi R. ATF6α downregulation of PPARα promotes lipotoxicity-induced tubulointerstitial fibrosis. Kidney Int, 95(3):577-589, 2019
  • Inoue T, Abe C, Kohro T, Tanaka S, Huang L, Yao J, Zheng S, Ye H, Inagi R, Stornetta RL, Rosin DL, Nangaku M, Wada Y, Okusa MD. Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/reperfusion injury in the kidney. Kidney Int, 95(3):563-576, 2019
  • Inoue T, Tanaka S, Rosin DL, Okusa MD. Bioelectronic Approaches to Control Neuroimmune Interactions in Acute Kidney Injury. Cold Spring Harb Perspect Med, 9(6):a034231, 2019
  • Abe C, Inoue T. Role of C1 neurons in anti-inflammatory reflex: Mediation between afferents and efferents. Neurosci Res, 136:6-12, 2018
  • Tanaka S, Inoue T, Hossack JA, Okusa MD. Nonpharmacological, Biomechanical Approaches to Control Inflammation in Acute Kidney Injury. Nephron, 137(4):277-281, 2017
  • Inoue T, Tanaka S, Okusa MD.Neuroimmune Interactions in Inflammation and Acute Kidney Injury. Front Immunol, 8:945, 2017 
  • Abe C*, Inoue T*, Inglis MA, Viar KE, Huang L, Ye H, Rosin DL, Stornetta RL, Okusa MD, Guyenet PG. *Equally contributed. C1 neurons mediate a stress-induced anti-inflammatory reflex in mice. Nat Neurosci, 20(5):700-707, 2017
  • Inoue T#. #Corresponding author. M1 macrophage triggered by Mincle leads to a deterioration of acute kidney injury. Kidney Int, 91(3):526-529, 2017
  • Inoue T, Rosin DL, Okusa MD. CAPing inflammation and acute kidney injury. Kidney Int, 90(3):462-5, 2016
  • Inoue T*, Abe C*, Sung SS, Moscalu S, Jankowski J, Huang L, Ye H, Rosin DL, Guyenet PG, Okusa MD. *Equally contributed. Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes. J Clin Invest, 126(5):1939-52, 2016
  • Katsura M, Cyou-Nakamine H, Zen Q, Zen Y, Nansai H, Amagasa S, Kanki Y, Inoue T, Kaneki K, Taguchi A, Mika Kobayashi M, Kaji T, Kodama T, Miyagawa K, Wada Y, Akimitsu N, and Sone H. Effects of Chronic Low-Dose Radiation on Human Neural Progenitor Cells. Sci Rep, 6:20027, 2016
  • Kitazawa T, Fujisawa K, Narboux-Nême N, Arima Y, Kawamura Y, Inoue T, Wada Y, Kohro T, Aburatani H, Kodama T, Kim KS, Sato T, Uchijima Y, Maeda K, Miyagawa-Tomita S, Minoux M, Rijli FM, Levi G, Kurihara Y, Kurihara H. Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process. Dev Biol, 402(2):162-74, 2015
  • Gigliotti JC, Huang L, Bajwa A, Ye H, Mace EH, Hossack JA, Kalantari K, Inoue T, Rosin DL and Okusa Ultrasound Modulates the Splenic Neuroimmune Axis In Attenuating Acute Kidney Injury. J Am Soc Nephrol, 26(10):2470-81, 2015
  • Maejima T*, Inoue T*, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I, Suehiro J, Sugiyama A, Kaneki K, Shibata H, Yoshinaka Y, Doi T, Asanuma A, Tanabe S, Tanaka T, Minami T, Hamakubo T, Sakai J, Nozaki N, Aburatani H, Nangaku M, Ruan X, Tanabe H, Ruan Y, Ihara S, Endo A, Kodama T, Wada Y. *Equally contributed. Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells. PLOS One, 9(5):e96005, 2014
  • Inoue T, Kohro T, Tanaka T, Kanki Y, Li G, Poh HM, Mimura I, Kobayashi M, Taguchi A, Maejima T, Suehiro JI, Sugiyama A, Kaneki K, Aruga H, Dong S, Stevens JF, Yamamoto S, Tsutsumi S, Fujita T, Ruan X, Aburatani H, Nangaku M, Ruan Y, Kodama T, Wada Y. Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements. Genome Biol, 15(4):R63, 2014
  • Imamura K, Imamachi N, Akizuki G, Kumakura M, Kawaguchi A, Nagata K, Kato A, Kawaguchi Y, Sato H, Yoneda M, Kai C, Yada T, Suzuki Y, Yamada T, Ozawa T, Kaneki K, Inoue T, Kobayashi M, Kodama T, Wada Y, Sekimizu K, Akimitsu N. Long noncoding RNA NEAT1-dependent PSF/SFPQ relocation between nuclear body paraspeckle and promoter region mediates IL8 expression in response to immune stimuli. Mol Cell,53(3):393-406, 2014
  • Tsuchida R, Osawa T, Wang F, Nishii R, Das B, Tsuchida S, Muramatsu M, Takahashi T, Inoue T, Wada Y, Minami T, Yuasa Y, Shibuya M. BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors. Oncogene, 33(29):3803-11, 2014.
  •  Mimura I, Nangaku M, Kanki Y, Tsutsumi S, Inoue T, Kohro T, Yamamoto S, Fujita T, Shimamura T, Suehiro J, Izumi A, Kobayashi M, Tanimura K, Inagaki T, Tanaka T, Hamakubo T, Sakai J, Aburatani H, Kodama T, and Wada Y. Dynamic change of the chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of HIF1 and KDM3A. Mol Cell Biol, 32(15):3018-32, 2012